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Branched-chain amino acids, leucine, isoleucine, and valine, when present in adequate concentrations, are supposed to maintain plasma glutamine concentration and cytokine (interleukin-1) production, while attenuating lymphocyte proliferation. This corresponds to maintaining the integrity of the immune system. Cytokines regulate immune and inflammatory responses and glutamine maintains skeletal muscle protein when the body's need for glutamine exceeds its natural production.
Prolonged, exhaustive exercise may cause the activity of the immune response cells to be suppressed. During such periods of metabolic stress, increasing the amount of glutamine made available would increase protein synthesis, maintain glutamine production, thereby maintaining activity of the immune response cells. If glutamine is not available, muscle catabolism (degradation, breakdown) proceeds and reductions in plasma glutamine concentration are likely, leaving the body's immune system more susceptible to invasion.
BCAAs also compete with tryptophan for transport across the blood-brain barrier. If tryptophan wins, it is converted to 5-hydroxytryptomine, leading to an increase in serotoninergic neurotransmitter activity. It is well known that serotonin-like activity causes central fatigue (the "Central Fatigue Theory"). Theory has it that if BCAAs are present in concentrations high enough to win the BCAA-tryptophan battle, BCAAs could reduce the exercise-induced tryptophan uptake by the brain, thus delaying fatigue. This would allow the athlete to continue to perform.
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I had the chance to discover the ISSA team, which made my dream possible, to become a certified trainer. With their outstanding vision, support and professionalism they guided me to reach the goal.
Mihnea Niculae Paraschivescu
With the knowledge, I've gained from the program. I feel confident to go into the work as a personal trainer now, and to start this phase in my life.
ISSA gave me the opportunity to work independently to study, complete work, and gain knowledge on becoming a personal trainer.
With ISSA guidance and textbooks, I have upgraded my knowledge to another level and I feel this by seeing big changes in my clients & myself!
The ISSA gave me a great knowledge of fitness programming, movement screening and nutrition.
ISSA has helped make my dreams com true of being a personal trainer and helping people become better versions of themselves.
The ISSA certified personal trainer program is the best experience of my life.
Being in ISSA family is my first steps in my international career, gold's gym trust Issa trainers, all world.
Omar A. Mahgoub
I found ISSA, and let me tell you it changed everything. I'm now a product of my passion, I get to share my love with my clients on a daily basis.
I am now one step closer to my visions. I can't wait to get out there and help others. I highly recommend this course to individuals who are interested in becoming a certified personal trainer.
Suresh Chalapathi Kumar Babu
I am really looking forward to helping people realize and reach their goals of becoming more healthy and physically fit, no matter their age.
The education I received will put me above my competition and has provided me to the tools to helps other meet their personal fitness goals.
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